ADVANCES AND CHALLENGES IN CRISPR/CAS-BASED FUNGAL GENOME ENGINEERING FOR SECONDARY METABOLITE PRODUCTION: A REVIEW

Advances and Challenges in CRISPR/Cas-Based Fungal Genome Engineering for Secondary Metabolite Production: A Review

Fungi represent an important source of bioactive secondary metabolites (SMs), which have wide applications in many gruvi golden lager fields, including medicine, agriculture, human health, and many other industries.The genes involved in SM biosynthesis are usually clustered adjacent to each other into a region known as a biosynthetic gene cluster (

read more

DDX39 Overexpression Predicts a Poor Prognosis and Promotes Aggressiveness of Melanoma by Cooperating With SNAIL

This study aimed to investigate the prognostic value and molecular mechanism of sara stedy stand aid DDX39 and its effector SNAIL in melanoma.First, overexpression of DDX39 in melanoma, which was identified by database analysis, was further validated in patient tissues.Cell growth, cell cycle, cell migration, and cell invasion assays were then perf

read more

A Novel Inverter-Side Current Control Method of $LCL$ -Filtered Inverters Based on High-Pass- Filtered Capacitor Voltage Feedforward

royal nomadic 5413 rug LCL filters have been widely used as the interface between inverters and power grids, but damping methods must be taken to solve the resonance of LCL filters.Considering overcurrent protection and inherent active damping, this paper focuses on the inverter-side current feedback (ICF) control.Some literatures have proposed tha

read more


Taxonomic revision of Madagascan Rhantus (Coleoptera, Dytiscidae, Colymbetinae) with an emphasis on Manjakatompo as a conservation priority

We review the diving-beetle genus Rhantus Dejean of Madagascar (Coleoptera, Dytiscidae, Colymbetinae) based on museum collection holdings and recently collected expedition material.Both morphology and DNA is used to test species boundaries, in particular whether newly collected material from the Tsaratanana mountains in the north represent a new sp

read more